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Advanced Instruments 3250 Freezing Point Osmometer for Clinical and Laboratory Use

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Sample Volume
0.20 to 0.25mL
Sample Capacity
Single Sample
Readout
20-character vacuum fluorescent display
Units
Milliosmoles per kg of H 2 O (mOsm/kg H 2 O)
Ranges
Low: 0 to 2000 mOsm/kg H 2 O High: 1400 to 4000 mOsm/kg H 2 O
All 15 specifications
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Specifications 15

Brands
Advanced Instruments
New/Used
Used
Sample Volume
0.20 to 0.25mL
Sample Capacity
Single Sample
Readout
20-character vacuum fluorescent display
Units
Milliosmoles per kg of H 2 O (mOsm/kg H 2 O)
Ranges
Low: 0 to 2000 mOsm/kg H 2 O High: 1400 to 4000 mOsm/kg H 2 O
Resolution
1 mOsm/kg H 2 O
Communication
On-board printer, RS-232 serial port
Linearity
Less than 0.5% from a straight line
Repeatability
0 to 400mOsm: Std. Deviation <2 mOsm/kg H 2 O 400 to 4000mOsm: Std. Deviation <0.5% of value mOsm/kg H 2 O
Drift
Less than 1mOsm/kg H 2 O per month
Dimensions
13x18x16”
Weight
23lbs
Electrical
100-240V, 50/60Hz, 1.4A

Product description

Precise freezing-point osmometer measuring osmolality from 0.20–0.25 mL samples with 1 mOsm/kg resolution.

The Advanced Instruments 3250 Osmometer is a high-precision laboratory instrument designed for accurate osmolality measurement via the freezing-point depression method. It utilizes a 0.20 to 0.25 mL sample volume, ideal for standard specimen testing in clinical diagnostics and biochemical research.

Key technical features include:

  • Microprocessor-controlled operation with automated freezing-point detection and temperature sensing for consistent results.
  • Measurement resolution of 1 mOsm/kg H₂O and excellent linearity with less than 0.5% deviation at reference conditions.
  • High repeatability: standard deviation <2 mOsm/kg H₂O for 0–400 mOsm and <0.5% for 400–4000 mOsm range, ensuring reliability in long-term use.
  • Measurement ranges from 0 to 2000 mOsm/kg H₂O (low) and 1400 to 4000 mOsm/kg H₂O (high), supporting diverse clinical and biotechnology applications like molecular diagnostics and bioprocessing quality control.
  • Single-sample capacity with an easy-to-read 20-character vacuum fluorescent display and multiple communication options including onboard printer and RS-232 serial port compatibility.
  • Rugged design with compact 13x18x16 inch dimensions and 23 lbs weight, suitable for standard laboratory benchtops.
  • Power compatibility of 100–240V, 50/60Hz to accommodate global laboratory settings.

This osmometer is essential for molecular biology workflows requiring precise osmolality analysis such as gene editing verification, synthetic biology experiments, and biopharmaceutical production pipelines. Its robust performance metrics meet the demands of clinical labs and research facilities conducting fluorescence analysis, live-cell imaging preparations, and other biotechnological investigations.

For lower sample volume needs, consider the Advanced Instruments 3320 Micro-Osmometer, which operates with 20 µL micro-samples, complementing workflows where specimen conservation is critical.

Overall, the Advanced Instruments 3250 Freezing Point Osmometer delivers reliable, reproducible osmolality data critical in molecular diagnostics, clinical chemistry, and bioprocess monitoring, making it a staple analytical tool in bioscience laboratories.

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Frequently asked questions

How long does laboratory equipment typically last?

With a service contract, ten to fifteen years is normal for most benchtop instruments. Detectors and pumps are the parts that wear first.

Can I get service for older equipment?

Often, yes. Verified suppliers frequently work with service partners converting the instrument. If applicable, we can list servicing options alongside the offer.

Where can I buy parts?

Ask a scientist through the request button. Parts are often available even when the instrument itself is discontinued.

What is the typical lead time for refurbished equipment?

Two to six weeks, depending on refurbishment scope and whether calibration is included.

Does laboratory equipment ship internationally?

We ship to 38 countries. Crating and customs handling are quoted with the instrument.

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Last updated 23 October 2026