Bruker Berkeley Lights Beacon CAS 2.4 Premium Single-Cell Optofluidic Analysis System

The Bruker Berkeley Lights Beacon CAS 2.4 Premium is a fully integrated single-cell cellular analysis optofluidic system designed for high-precision, automated manipulation and imaging of individual cells. This advanced platform combines state-of-the-art microfluidics, semiconductor optics, and nanofluidic technology, making it critical in biopharmaceutical production pipelines and widely adopted in synthetic biology research.

Key technical features include:

• Optofluidic single-cell manipulation using patented OptoSelect chips with light-driven cell positioning into NanoPen chambers (volume 500 pL to 1 nL).
• Fluorescence imaging module equipped with Nikon Plan Fluor 10x/0.30 DIC-capable and 4x/0.28 objectives, paired with a high-sensitivity Andor Zyla sCMOS camera for live-cell visualization and fluorescence analysis.
• Integrated multi-channel microfluidic control with reagent reservoirs and chip docking interface allowing sequential and simultaneous multi-assay workflows critical to molecular diagnostics and cell line development.
• DLP-based optoelectronic positioning (OEP) system enabling precise patterned light control for single-cell sorting and analysis.
• Environmental control via Ibidi CO₂/O₂ gas mixer controller supporting live-cell culture conditions from 10°C to 40°C for sustained cell viability during analysis.
• Automated reagent handling system for streamlined operation in bioprocessing and functional immune cell profiling applications.

This system supports key research areas such as:

• Single-cell antibody discovery and screening
• Phenotype-to-genotype correlation studies essential for gene editing and synthetic biology workflows
• Functional immune cell profiling relevant to clinical diagnostics and cell therapy development
• Live-cell secretion and binding assays that support biomanufacturing quality control

Technical details:

• Power: 110–240 V AC, 50–60 Hz
• Dimensions: 46 in (W) × 34 in (D) × 71.5 in (H)
• Weight: approximately 1,260 lb
• Gas supply: Clean dry air (CDA) and >99% CO₂ gas required

This system is optimized for biotechnology laboratories requiring automated, high-throughput single-cell analysis. It is essential for researchers engaged in biotechnology, molecular biology, and biomedical engineering seeking precise single-cell manipulation combined with real-time optical monitoring. The Berkeley Lights Beacon platform is widely used in bioprocessing environments where reproducible single-cell assays and live-cell exports enhance productivity in molecular cloning workflows.

The package includes the workstation with keyboard and monitor, Cell Analysis Suite (CAS) v2.4 Premium software, Assay Analyzer 2.4, Nikon objectives, fluorescence illumination, laser module, fluidics system, and gas mixer controller. Consumables such as OptoSelect chips must be purchased separately.

This system is sold as-is, providing a robust solution for laboratories aiming to accelerate discovery in immunology, synthetic biology, and molecular diagnostics through cutting-edge single-cell optofluidic technology.