Leica DMi8 Inverted LED Fluorescence Motorized Microscope with New Filter Sets

The Leica DMi8 Inverted LED Fluorescence Motorized Microscope is a versatile research platform designed for advanced live-cell and fixed-cell imaging applications, widely used in biotechnology, molecular diagnostics, and clinical research. This microscope combines brightfield and fluorescence modalities, equipped with a motorized 6-position fluorescence filter turret and fluorescence illumination by a Lumencor SOLA Light Engine, supporting up to six fluorescence filter cubes for multi-channel imaging workflows critical in synthetic biology and bioprocessing.

Key features include:

• Inverted microscope base with CTR advanced control for precise motorized operation
• Fluorescence light path integrated with motorized filter cube turret (6-position) and Lumencor SOLA LED light source, optimized for dyes such as DAPI, FITC, Texas Red, Cy3, and Cy5, essential for molecular cloning and gene editing research
• Brightfield illumination via Leica TL LED 12V lamp with built-in power supply for phase contrast and transmitted light imaging
• Motorized condenser turret with seven positions and phase inserts (PH0, PH1, PH2) enhancing contrast in unstained or live-cell samples
• Objective turret with six positions, supplied with Leica N Plan and Leica HC PL Fluotar objectives from 5x to 40x magnification, enabling high-quality imaging for cell morphology and confluency studies
• Fixed mechanical XY stage with optional motorized stage upgrade for automated slide scanning and high-content screening workflows
• Dual camera ports (100% eyepiece, 100% camera) and Leica DFC3000 G monochrome fluorescence camera with C-mount adapter, designed for quantitative fluorescence imaging and image documentation
• Comprehensive software suite (Leica LAS X) enabling still image capture, live video, multi-frame time-lapse, z-stack acquisition, annotation, and advanced image analysis critical in biomanufacturing and phenotypic assays

The system is fully serviced with new fluorescence filter sets including DAPI, EGFP/FITC, TRITC/Cy3, Texas Red, and Cy5 configurations, ensuring optimal filter and illumination performance verified at the specimen plane. Preventive maintenance has been completed, and the microscope is backed by warranty and remote training sessions, enhancing user proficiency in fluorescence microscopy techniques widely adopted in neuroscience, cell imaging, and synthetic biology research.

Customizable upgrades include:

• Additional fluorescence filter cubes and alternative excitation sources (Xenon, Metal Halide, LED) for expanded spectral imaging in molecular diagnostics
• Motorized XY stage and joystick controller for automated bioprocessing imaging workflows
• Higher magnification and apochromatic objectives to improve resolution in live-cell and fixed-sample imaging
• Advanced CCD, sCMOS, and EMCCD cameras for higher sensitivity and faster acquisition rates in fluorescence and brightfield imaging

This Leica DMi8 inverted fluorescence microscope is ideal for researchers requiring a motorized, flexible imaging system that supports complex fluorescence analysis, time-lapse experiments, and quantitative measurements integral to biopharmaceutical production pipelines, cell biology, and biomedical engineering domains. It offers precise optical and mechanical performance verified against industry standards for field distortion, uniformity, and fluorescence intensity, making it a reliable tool in biotechnology and molecular biology laboratories.

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Keywords incorporated: inverted fluorescence microscope, motorized fluorescence microscope, live-cell imaging, fluorescence filter cubes, bioprocessing imaging, molecular diagnostics, synthetic biology, gene editing research, biomanufacturing, cell morphology analysis, multi-channel fluorescence imaging, time-lapse microscopy, high-content screening.