Advanced Instruments Solentim Cell Metric CLD High Contrast Automated Imager Unit 3

The Advanced Instruments Solentim Cell Metric CLD High Contrast Imager Unit 3 is a precision automated imaging system engineered for cell line development and single-cell identification crucial to biotechnology and molecular diagnostics workflows. This system integrates a high-contrast brightfield optical setup with automated plate handling, supporting a temperature-controlled stacker accommodating up to 10 plates per operation, optimizing throughput for monoclonality and viability analysis.

Key Features:

• Automated imaging using a 10x objective and 650 nm laser illumination (max average power 850 µW)
• Supports multiple plate formats: 96-well plates (including BD Falcon, Corning CellBIND, Eppendorf Clear) and manual scan modes for 6, 12, 24, and 48-well plates
• High-resolution whole-well brightfield imaging for precise tracking of cell growth and colony formation
• Data storage optimized for large imaging projects, approximately 150 MB per whole plate image, scaling to around 3 GB for typical 14-day studies
• Motorized stage ensures reproducible, automated scanning for consistent image acquisition critical in clone screening and regulatory submissions for monoclonality assurance
• Non-invasive imaging preserves cell viability while enabling automated cell count and viability analysis

Applications:

• Single-cell cloning verification and monoclonality assurance essential in molecular biology, bioprocessing, and synthetic biology research
• High-resolution monitoring of cell growth dynamics in biomanufacturing pipelines
• Clone screening and selection processes in therapeutic cell line development
• Supports regulatory compliance needs via robust imaging data for cell line characterization

System Components Included:

• Cell Metric CLD High Contrast Imager
• Automated plate loader with 10-plate cassette capacity
• Two 24V power supplies with cables (computer/software license not included)

This instrument serves as the predecessor to the Solentim Cell Metric X HT model and is widely adopted in biopharmaceutical production pipelines where precise single-cell imaging is fundamental. Though sold as-is without software or warranty, this unit represents a valuable tool for laboratories specializing in live-cell imaging, fluorescence analysis, and cell growth monitoring across diverse biotechnology applications.

This imager is critical for researchers focused on establishing monoclonal cell lines with verifiable clonality, making it essential equipment for gene editing, molecular cloning workflows, and cell line development integrated into advanced clinical diagnostics and biomedical engineering projects.