Thermo Scientific AccelerOme Automated Proteomic MS Sample Preparation Platform with Integrated Thermal Mixer and In-line Peptide Quantification

The Thermo Scientific AccelerOme Automated Proteomic MS Sample Preparation Platform is a benchtop automated system designed for streamlined and reproducible proteomic sample preparation workflows, essential in molecular diagnostics, synthetic biology, and bioprocessing research. It supports automated protein digestion, cleanup, isobaric tagging (e.g., TMT labeling), peptide desalting, and enrichment to optimize high-throughput LC-MS/MS workflows used in molecular biology and biotechnology applications.

Key technical features include:

• Sample capacity: Accommodates up to 36 label-free samples, 33 TMT11plex, or 32 TMTpro 16plex samples per run, supporting protein inputs from 10 µg to 100 µg per sample.
• Integrated thermal mixer: Precise temperature control from 6 °C to 40 °C with ±1.5 °C accuracy at 50 °C, enabling consistent thermal incubation and shaking to facilitate enzymatic digestion and reagent mixing.
• Built-in spectrophotometer: Provides in-line peptide quantification with a UV limit of detection of 50 ng/µL, allowing real-time quality control without workflow interruption.
• Robotic arm and fluidics: Precision automated liquid handling with a multi-axis robotic arm, syringe pump, and valve system for accurate reagent dispensing and sample processing, critical for reducing variability and improving reproducibility in molecular diagnostics workflows.
• Software suite: Experiment Designer software offers wizard-guided setup including automatic TMT plex assignment, randomization, and statistical power estimation, with output files compatible with Xcalibur and Proteome Discoverer software, widely used in proteomic analysis.
• Physical footprint: Compact benchtop device measuring 88.5 × 84.2 × 63.5 cm and weighing 70 kg, designed for integration into multidiscipline biomanufacturing or clinical research laboratories.
• Power requirements: Compatible with 100–240 V, 50/60 Hz power sources.

This platform plays a critical role in workflows requiring automated, reproducible proteomic sample preparation, making it a valuable tool in biotechnology, biomedical engineering, molecular cloning, and biopharmaceutical production pipelines. Its automation significantly reduces hands-on time and experimental bias, increasing throughput and reliability for quantitative proteomics research and molecular diagnostics.

The system has been fully tested and serviced, ensuring all subsystems—including thermal control, robotic motion, fluid handling, valve alignment, and spectrophotometric detection—meet stringent performance standards. This makes the AccelerOme platform a dependable solution widely adopted in synthetic biology, neuroscience proteomics, and advanced bioprocessing laboratories.

Primary keywords like "automated proteomic sample preparation," "TMT labeling workflows," and "in-line peptide quantification" are integrated naturally, alongside long-tail biotechnology phrases such as "critical in biopharmaceutical production pipelines" and "widely adopted in synthetic biology research." This description targets laboratory buyers, researchers, and clinical professionals involved in proteomics and molecular diagnostics, emphasizing the platform's technical capabilities and application relevance.