Pall Allegro Single-Use Automated Tangential Flow Filtration System for Bioprocessing UF/DF

The Pall Allegro TFF System Single Use Automation UF/DF is a fully automated tangential flow filtration system designed specifically for biopharmaceutical bioprocessing applications including protein concentration, recombinant molecule purification, and vaccine manufacturing. Utilizing single-use, gamma-irradiated manifolds, the system effectively eliminates cross-contamination risks essential for maintaining sterility in molecular diagnostics and gene editing workflows.

Key technical features include:

• Flow rate capacity of 1000 L/hour, supported by a high precision positive displacement diaphragm pump ensuring pressure-independent flow control
• Compatibility with 20L or 100L retentate biocontainers, supporting fed-batch operations common in biomanufacturing and synthetic biology research
• Integration of pressure and flow sensors enabling real-time monitoring and control critical for process optimization in bioprocess engineering
• Applicable to ultrafiltration and diafiltration cassette sizes ranging 0.5 to 2.5 m², facilitating scalability for diverse bioprocess volumes
• Operates in both automatic and manual modes, enhancing flexibility in process control and adaptation to varying bioprocessing needs
• Designed for single-use applications, reducing cleaning requirements and the risk of contamination, making it suitable for fast-paced biopharmaceutical production pipelines

Manufactured in 2017, the Allegro TFF System’s dimensions and weight (203.2 cm x 127 cm x 177.8 cm; 544.31 kg) make it a robust benchtop solution for biotechnology laboratories. The inclusion of power and data cables ensures seamless integration with laboratory control systems, supporting critical bioprocess analytics.

This system is widely used in molecular cloning workflows, synthetic biology, and large-scale bioprocessing, and is considered essential equipment for maintaining process integrity in industrial-scale biomanufacturing and clinical diagnostics. The Pall Allegro TFF platform optimizes ultrafiltration and diafiltration steps, enabling high-efficiency purification processes that are vital in biotechnology and pharmaceutical research environments.