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Procurable · sourced on request

Calbiochem PD98059

UsedCalbiochemCell countersNetherlands
Procurable

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Molecular Weight
267.28 g/mol
Purity
>98%
Chemical Formula
C16H13NO3
CAS Number
167869-21-8
Solubility in DMSO
46 mg/mL (172.1 mM)
Availability
Procurable
Lead time
Confirmed with your quote
All 16 specifications
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Specifications 16

Brands
Calbiochem
New/Used
Used
Molecular Weight
267.28 g/mol
Purity
>98%
Chemical Formula
C16H13NO3
CAS Number
167869-21-8
Solubility in DMSO
46 mg/mL (172.1 mM)
Solubility in Ethanol
1 mg/mL (3.7 mM)
Solubility in Methanol
0.7 mg/mL (2.6 mM)
Storage Temperature
4°C
Stability at -20°C
Up to 2 years
Storage Conditions
Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.
Shipping Conditions
Shipped at room temperature.
Appearance
Crystalline solid
Availability
Procurable
Lead time
Confirmed with your quote

Product description

Potent, selective MEK1/2 inhibitor with >98% purity, soluble to 75 mM in DMSO for cell signaling studies.

Calbiochem PD98059 is a potent, cell-permeable inhibitor of MEK1/2 (mitogen-activated protein kinase kinase 1 and 2), effectively blocking the activation of the MAPK/ERK signalling pathway. This inhibition is crucial for researchers investigating cellular processes such as proliferation, differentiation, and survival.

Key features include:

  • Selective inhibition: Targets MEK1/2 without affecting other kinases, ensuring specificity in experimental outcomes.
  • High purity: Supplied at >98% purity, guaranteeing consistent and reliable results.
  • Solubility: Soluble up to 75 mM in DMSO, facilitating ease of use in various assay conditions.

PD98059 is widely utilised in:

  • Cancer research: Studying the role of the MAPK/ERK pathway in tumour growth and response to therapies.
  • Neuroscience: Investigating neuronal signalling and neurodegenerative diseases.
  • Molecular biology: Exploring cell signalling mechanisms and gene expression regulation.

Commonly employed in:

  • University laboratories: For academic research and teaching purposes.
  • Biomedical research centres: Conducting translational studies to bridge laboratory findings with clinical applications.
  • Pharmaceutical companies: Developing and testing new therapeutic agents targeting the MAPK/ERK pathway.

First introduced in the mid-1990s, PD98059 remains a valuable tool in scientific research, particularly in the biotechnology sector, for elucidating complex signalling pathways and developing targeted therapies.

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Frequently asked questions

How long does laboratory equipment typically last?

With a service contract, ten to fifteen years is normal for most benchtop instruments. Detectors and pumps are the parts that wear first.

Can I get service for older equipment?

Often, yes. Verified suppliers frequently work with service partners converting the instrument. If applicable, we can list servicing options alongside the offer.

Where can I buy parts?

Ask a scientist through the request button. Parts are often available even when the instrument itself is discontinued.

What is the typical lead time for refurbished equipment?

Two to six weeks, depending on refurbishment scope and whether calibration is included.

Does laboratory equipment ship internationally?

We ship to 38 countries. Crating and customs handling are quoted with the instrument.

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Last updated 4 November 2026