K&A H 16 Automated DNA/RNA/LNA Synthesizer with 16-Column Capacity

The K&A H 16 DNA / RNA Synthesizer is a precision automated oligonucleotide synthesizer designed for simultaneous synthesis across 16 columns. Optimized for biotechnology and molecular diagnostics applications, this instrument supports high-purity synthesis of DNA, RNA, and LNA oligomers critical in gene editing, synthetic biology, and bioprocessing workflows.

Key features include:

• 16 column capacity supporting standard or universal controlled pore glass (CPG) solid supports
• 12 amidite reagent positions with 1g/2g bottles and 4 positions for 4 ml amidites, plus 2 offline 4 ml amidite positions for flexible reagent management
• 9 reagent positions with customizable bottle closures on customer request
• Programmable synthesis scale up to 10 µmol, enabling tailored reaction volumes
• Integrated online trityl monitoring for continuous tracking of synthesis progress on all columns, collecting all released trityl groups
• Flexible, fully programmable synthesis control allowing new synthesis starts at any column position during the run
• Single-line column design with rocking mechanism over the mixing chamber enables efficient mixed base synthesis and automated antisense oligonucleotide production
• Fast cycle times of 5.5–6 minutes for 16-column synthesis, reducing reagent consumption and increasing throughput
• Compact footprint measuring 35 × 60 × 45 cm, suitable for constrained lab spaces

This synthesizer is essential for biopharmaceutical production pipelines and synthetic biology research demanding long oligonucleotides with superior purity and precise sequence fidelity. Its capabilities make it widely adopted in molecular cloning workflows, biomedical engineering, and clinical diagnostics requiring custom oligonucleotide libraries.