Pall iCELLis Nano Single-Use Fixed-Bed Bioreactor System with mPath Controller

The Pall iCELLis Nano Single-Use Fixed-Bed Bioreactor system is designed for advanced adherent cell culture applications, offering automated operation and a compact fixed-bed design suitable for bioprocessing workflows in biotechnology and molecular diagnostics. The system integrates a single-use fixed-bed bioreactor pre-packed with proprietary macrocarriers fabricated from Class VI polyester microfibers, providing up to 500 m² of growth surface area, equivalent to approximately 3,000 roller bottles. This configuration supports scalable, high cell density cultivation critical for biomanufacturing and gene editing research.

Key technical features include:

• Automated single-use bioreactor designed to simplify processes from vial inoculation to final product harvest, reducing hands-on operational steps.
• Pre-installed calibrated probes within the disposable bioreactor ensure precise monitoring and control of critical parameters.
• A unique waterfall oxygenation system promotes efficient O2 transfer and CO2 stripping, achieving high kLa values essential for optimal cell viability and productivity.
• Magnetic drive impeller delivers gentle agitation with evenly distributed media circulation, minimizing shear stress on sensitive adherent cells.
• Streamlined seed train allows inoculation at very low cell densities (as low as 3,000 cells/cm²), optimizing resources and reducing culture times.
• Scalable design facilitating predictable transition from R&D-scale experiments to commercial manufacturing batches, supporting synthetic biology and molecular cloning applications.

This bioreactor system is widely adopted in biotechnology research and biopharmaceutical production, particularly where 3D cell culture models and high-density adherent cell expansion are essential. The compact footprint and disposable components reduce capital expenditure and operational costs compared to traditional stirred tank or roller bottle systems, making the iCELLis Nano an essential platform for molecular diagnostics and live-cell bioprocessing in industrial and academic settings.