Getinge Applikon my-Control 0.5L Autoclavable Bioreactor System for Small-Scale Cell Culture

The Getinge Applikon my-Control Autoclavable Bioreactor System Unit 3 is a benchtop bioreactor controller designed for precise control of small-scale cell culture and bioprocess development. Featuring a 0.5-liter glass MiniBio 500 reactor with a working volume of 100–400 mL, this system supports critical process parameters essential in biotechnology research and molecular diagnostics.

Key technical features include:

• Integrated inputs for pH, temperature, dissolved oxygen (DO), agitation, and liquid level measurement.
• Gas supply with four mass flow controllers (MFCs) enabling controlled delivery of N2 (160 mL/min), Air (160 mL/min), O2 (40 mL/min), and CO2 (40 mL/min) for optimized aeration and metabolic control.
• Three variable speed peristaltic pumps (0–200 rpm) support automated liquid handling, feed control, and pH regulation via CO2 and alkali addition.
• Direct drive brushless stirrer motor (M01.1) with maximum speeds of 50–1750 rpm and impeller tip speed of 2.0 m/s ensures homogeneous mixing with a marine impeller.
• Temperature control is managed by an electrical heating blanket and cooling condenser integrated within the jacketed bioreactor chamber.
• Level control uses a variable speed pump to add or remove liquids, providing flexibility in process management.

The modular design allows easy customization with single-use or autoclavable sensors including pH, dissolved oxygen (DO), oxidation-reduction potential (ORP), and others to accommodate evolving research needs.

This system is widely used in:

• Cell culture fermentation and bioprocess scale-up studies
• Media optimization and strain screening
• Biomass and metabolite production critical in biopharmaceutical manufacturing and synthetic biology pipelines
• Process development in biotechnology and molecular biology laboratories

All components are tested for functional reliability, including pumps, sensors, stirrer motor, and gas mixing system. The unit supports seamless integration with laptops and communication cables, optimized for reliable data acquisition and process monitoring.

The my-Control Autoclavable Bioreactor System is an essential tool for researchers and bioprocess engineers seeking precise environmental control, automated feeding strategies, and scalable small-volume bioprocess experiments. It offers robust support for applications in molecular diagnostics, bioprocessing, and gene editing workflows requiring rigorous culture condition control.

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Keywords integrated:

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