Teledyne ISCO ACCQPrep HP150 UV-Vis Preparative Liquid Chromatography System with Autosampler

The Teledyne ISCO ACCQPrep HP150 is a high-performance preparative liquid chromatography system designed for automated compound purification, peptide isolation, and reaction cleanup, widely used in biotechnology and molecular diagnostics workflows. Its fully integrated platform features a 150 mL/min maximum flow rate with ±2% accuracy and supports pressures up to 6000 psi (414 bar), enabling robust bioprocessing and biopharmaceutical purification applications.

Key components include the ACCQPrep AI 5 AutoInjector for precise, programmable sample introduction, the AS 2x2 autosampler module for unattended queued injections, and the ACCQPrep CSV 4 column selector valve alongside the SSV 2x3 solvent selector valve module for flexible solvent and column switching. UV-Vis detection covers 200 to 800 nm wavelengths with ±5 nm increments, facilitating absorbance tracking critical in synthetic biology and molecular cloning purification steps.

The system’s high-pressure, dual-piston reciprocating pumps provide accurate gradient formation (linear, step, isocratic) with ±1% gradient linearity, ensuring stable mixing and consistent solvent delivery optimized for fraction collection workflows. Designed for ambient operation at 20–40°C, the platform allows internal and external fraction collection and supports multiple solvents in up to 2 x 3 configurations.

Technically validated for flow accuracy, sample handling reproducibility, solvent routing, UV lamp performance, and gradient stability, this system ensures reliable preparative chromatography with minimal carryover or cross-fraction contamination—essential for demanding biotechnology, peptide purification, and natural product isolation applications.

Dimensions are 27.5" x 14" x 20", weighing 93.2 lbs, with the autosampler module measuring 18.9" x 14" x 19.3" and 27.3 lbs. Power requirements are 100–240 VAC, 50/60 Hz.

This setup is popular among researchers in biomedical engineering, cell imaging, and clinical diagnostics requiring accurate, unattended prep-scale purification with integrated UV-Vis absorbance tracking and multi-column solvents management. It is critical in biopharmaceutical production pipelines and molecular biology workflows for automated and reproducible purification of complex samples.