Teledyne ISCO CombiFlash NextGen 300+ Flash Chromatography System with UV Detection

The Teledyne ISCO CombiFlash NextGen 300+ is a high-precision flash chromatography system designed for organic synthesis product purification, natural product isolation, and compound library separation—critical in biopharmaceutical production pipelines and molecular diagnostics workflows. Featuring a single precision pump delivering flow rates from 1 to 300 mL/min with ±5% accuracy (5–200 mL/min), it supports binary gradients with up to 4 solvent inlets and maintains gradient accuracy at ±2% of full scale. The system operates at pressures up to 20 bar (300 psi), facilitating faster purification runs with diverse stationary phases.

Equipped with an integrated UV detection system spanning 200 to 400 nm, the CombiFlash NextGen 300+ offers real-time fraction tracking and collection—essential for synthetic biology research requiring precise compound isolation. Its modular, compact footprint (26 x 14.1 x 17 in) and weight of 61 lb minimize benchtop space while maintaining robust throughput.

Key features include:

The system is thoroughly tested for precision pump function, gradient accuracy, UV lamp performance, RFID column detection, and reliable fraction collection, ensuring stable flow without gradient drift or baseline instability. This makes it an optimal choice for bioprocessing workflows, synthetic biology research, and biomanufacturing pipelines requiring reproducible and high-throughput chromatographic purification.

Power requirements span 100–240 VAC, 50/60 Hz, and standard accessories include intake hoses, waste hoses, and power cabling. Optional racks, solid load caps, and accessories are available for customization.

In summary, the Teledyne ISCO CombiFlash NextGen 300+ is a compact, versatile flash chromatography system that delivers precise gradient control and real-time UV fraction monitoring, making it indispensable in biotechnology laboratories focused on molecular diagnostics and bioprocess scale-up.