Prometheus NT.48 Protein Folding Analyzer

The Prometheus NT.48 by Nano Temper Technologies is a high-resolution protein stability analyzer designed for meticulous protein stability characterization without the need for external dyes. This unit is operational and ready for immediate deployment. The instrument is especially beneficial in drug development, aiding in the analysis of protein-based therapeutics. It features Native DSF for dye-free detection, two UV detectors for detailed fluorescence monitoring, and high-resolution detection crucial for aggregation and thermal stability monitoring.

With the capacity to handle 48 samples in parallel, the Prometheus NT.48 is ideal for high-throughput experiments. It accommodates a wide concentration range from 5 µg/mL to 250 mg/mL and operates at temperatures between 15 °C and 95 °C for comprehensive stability analysis. Its intuitive software simplifies operation and analysis, and its maintenance-free design ensures durability even with challenging samples. Optional backreflection optics enhance light scattering detection for studying protein aggregation.

The instrument delivers high sensitivity and reproducibility, making it suitable for applications such as thermal and chemical denaturation studies. It supports PR.ThermControl and PR.Stability Analysis software, ensuring compliance with 21 CFR Part 11 for regulated settings. The Prometheus NT.48 is indispensable for thermal unfolding studies, chemical unfolding stability analyses, aggregation detection, and the development and screening of protein formulations.