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Molecular Devices ImageXpress Micro Confocal HT.ai High-Content Laser Imaging System with Robotic Automation and Environmental Control
Product Description
The Molecular Devices ImageXpress Micro Confocal HT.ai is a high-content laser scanning confocal microscope designed for automated, high-throughput live-cell and fixed-sample imaging. It integrates advanced optical sectioning, robotic sample handling, and environmental regulation for precise and reproducible experiments in biotechnology and molecular diagnostics.
Key technical features include:
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Optical and Imaging Components:
- Andor Zyla sCMOS camera for high-sensitivity detection
- 89 North LDI-NIR EX light engine (Class 4 Laser) with multiple laser lines at 405, 445, 470, 520, 555, 640, 730 nm for multiplexed fluorescence assays
- Nikon objectives: 4x/0.20 Plan Apo, 10x/0.45 Plan Apo Lambda, 20x/0.95 Water Apo Lambda S LWD, 40x/1.15 Water Apo Lambda S LWD for superior resolution, especially in aqueous 3D specimens
- Spinning disk confocal geometry with 50 µm slit and 60 µm pinhole dual-disk system enabling rapid confocal imaging
- High-speed laser autofocus and integrated image autofocus for consistent focus in multi-well and time-lapse experiments
- 4-position automated objective changer and 5-position dichroic and 8-position emission filter wheels with installed emission filters (DAPI, FITC, CFP, Texas Red, CY5, CY7, YFP) to cover broad fluorescent channels
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Automation and Sample Handling:
- Brooks PreciseFlex 400 robotic arm with 750 mm Z travel and extended reach capability for precise plate manipulation
- Supports up to four 20-position plate hotels, barcode reading, and multiple SBS-format microplates (1 to 1536 wells, round/flat bottom, low to high profile)
- Throughput exceeding 160,000 wells/day in confocal mode and over 200,000 wells/day widefield for large-scale screening and bioprocessing applications
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Environmental Control Features:
- FC-9 Gas Mixer enabling multi-day live-cell imaging with controlled CO₂ (5–10%), humidity regulation, and temperature maintenance at 30–40 °C ±0.5 °C to mimic physiological conditions
- Water immersion control box ensures stable water layer for high numerical aperture water immersion objectives, enhancing imaging quality in live-cell and thick sample applications
- Transmitted light imaging option with Nikon 100W halogen lamp arm delivers brightfield/phase contrast capabilities for morphology visualization independent of fluorescence
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Software and Workflow Integration:
- MetaXpress 6.7 software enables time-series acquisition, Z-stack capture, 3D image analysis, asynchronous kinetics, peak analysis, and customized analysis workflows essential for synthetic biology and molecular biology research
- Biosero Green Button Go automation software for seamless control of imaging and robotic sample handling, supporting high-throughput biomanufacturing screening pipelines
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Robotic Arm Specifications:
- Repeatability ±0.090 mm, resolution ~10 µm, max acceleration 2500 mm/s², max Cartesian speed 500 mm/s with 500 g payload for reliable plate handling
- Spring gripper with adjustable force controls, supports pick-and-place in landscape and portrait orientations
This system supports critical workflows in biotechnology, including high-content phenotypic screening, gene editing analysis, 3D organoid imaging, and molecular diagnostics. Its comprehensive automation and environmental features make it widely adopted in research fields like cell imaging, biomedical engineering, and biopharmaceutical production pipelines.
Primary keywords: high-content confocal microscope, laser imaging system, live-cell imaging, robotic sample handler, environmental control microscope, water immersion optics
Long-tail phrases included naturally: "widely used in high-throughput biopharmaceutical screening," "essential for live-cell and 3D organoid imaging," "critical for multiplexed fluorescence assays in synthetic biology," "supports multi-parameter cellular readouts in molecular diagnostics," and "integrated automation for bioprocessing workflows."
Item Stats
Product details
| Stock | In Stock |
| Brand | Molecular Devices |
| Product Code | 64366 |
| Condition | Pre-Owned |
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