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Cytiva Pall iCELLis Nano Single-Use Fixed-Bed Bioreactor System with 3-Fold Capacity

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Product Description

The Cytiva Pall iCELLis Nano Single-Use Fixed-Bed Bioreactor System, 3-Fold configuration offers an integrated solution for small to moderate scale adherent cell culture bioprocessing, widely adopted in molecular diagnostics, gene therapy vector production, and viral vaccine manufacturing.

Key technical features include:

  • Fixed-bed surface area ranging from 0.5 to 4 m² with bed diameters of 11 cm and selectable heights of 2, 4, or 10 cm, optimizing surface area for cell growth.
  • Magnetic drive impeller agitation system operating between 100 to 1500 rpm, ensuring gentle yet effective mixing suitable for sensitive adherent cells.
  • Compatible with inline sensors for pH, dissolved oxygen (DO), temperature, and advanced biomass monitoring (biomass sensor sold separately), supporting enhanced process analytical technology (PAT).
  • Control architecture featuring the mPath Control Tower and Pall Link software version 1.5.1, facilitating precise process control and data acquisition required in biomanufacturing workflows.
  • Advanced gas handling system includes six pre-calibrated thermal mass flow controllers (TMFCs) for air, O₂, CO₂, and N₂, allowing flexible and accurate gas mix control critical for process optimization in bioprocessing and cell culture environment control.
  • Temperature control utilizes Peltier elements maintaining a tight operating range of 20 - 40 °C, with reusable PT100 temperature sensors for precise thermal regulation.
  • Electrochemical sensors for DO control (0-150% air saturation) and pH measurement (0-14 range) ensure stable culturing conditions.
  • Pumps configured with one fixed speed for base addition and two variable speed pumps designed for perfusion in-out processes, supporting scalable bioprocess operations.
  • Dimensions of the controller and docking stations are compact (controller: 23×60×45 cm, 20 kg; docking station: 34×36×29 cm, 6.7 kg), enabling space-efficient laboratory integration.

This 3-fold system configuration triples processing capacity, making it ideal for seed train expansion, cell-based feasibility studies, and optimized monoclonal antibody or viral vector production in biotechnology research and pharmaceutical biomanufacturing. The single-use design reduces contamination risks while supporting scalable and reproducible adherent cell culture processes critical in synthetic biology and gene editing workflows.

Applications include:

  • Viral vaccine production (e.g., influenza, measles)
  • Manufacturing of gene therapy viral vectors (AAV, lentivirus)
  • Adherent cell line cultivation for monoclonal antibody production
  • Process optimization and scale-up for adherent cell cultures
  • Seed train or inoculum expansion for large-scale bioreactors

This system does not include disposable bioreactor vessels, sensors, or tubing manifolds, which must be procured separately. It is supplied with fully functional control towers, docking stations, filter heaters, temperature sensors, pH and DO sensor cables, and the PallLink Computer Controller, tested and validated by certified technical service.

Optimized for biotechnology workflows, this system supports critical parameters monitoring, gas mixing precision, and gentle agitation—essential for sensitive cell culture applications including molecular cloning, synthetic biology research, and biopharmaceutical production pipelines. The iCELLis Nano system enables seamless scale-up from research to production, making it a versatile tool in advanced bioprocessing and molecular diagnostics laboratories.


Item Stats

Status
For Sale
State
used
Brand
Pall
Location
Walpole - United States

Product details

StockIn Stock
BrandPall
Product CodeSM101463-3F
ConditionPre-Owned

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From €29,860.57*ex. VAT

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