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Cytiva ÄKTA oligopilot plus 100 Automated Oligonucleotide Synthesizer for Process Development
Product Description
The Cytiva ÄKTA oligopilot plus 100 is an advanced, fully automated oligonucleotide synthesizer designed for small- to medium-scale DNA and RNA synthesis ranging from 50 μmol to 9 mmol. Utilizing flow-through reactor technology, it enables precise control of reaction rates, scalable synthesis, and minimized reagent consumption. Its column re-circulation feature enhances coupling times, critical for demanding syntheses such as RNA and modified nucleotides, making it essential for molecular diagnostics, gene editing, and synthetic biology research.
Key features include:
- Seven column positions and support for up to twelve monomer reagents, allowing flexibility in oligonucleotide chemistries
- Compatibility with a broad range of column reactors, from fixed volumes (1.2 mL–48 mL) to adjustable FineLINE scales (250 μmol–4 mmol) and custom volumes up to 9 mmol
- Online UV and conductivity monitoring integrated into the UNICORN 21 CFR Part 11 compliant software, offering full synthesis documentation, batch operation aligned with cGMP and GLP requirements, and Process Analytical Technology (PAT) capabilities
- Pressure-controlled flow and UV-based conditional method programming optimize column washing to reduce overall cycle time
- Supports a variety of oligonucleotide therapeutic developments including RNAi, siRNA, aptamers, antisense oligonucleotides, immunostimulatory CpG motifs, and exon skipping compounds
The system’s robust automation and scalable synthesis capacities make it popular among researchers in biotechnology, molecular cloning workflows, and biopharmaceutical production pipelines, ensuring efficient synthesis with high product purity and reproducibility. The ÄKTA oligopilot plus 100 enables seamless scale-up and process development, critical for innovative genomic and therapeutic oligonucleotide applications.
Item Stats
Product details
| Manufactured | Please ask. |
| Location | Gräfelfing, Bavaria, Germany |
| Specification | refurbished |
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