ÄKTA Pilot 400 Pilot-Scale Oligonucleotide Synthesis and Bioprocess Chromatography System

The ÄKTA Pilot 400 by Cytiva is a pilot-scale bioprocess chromatography system designed for the efficient synthesis of oligonucleotides in the 4 to 60 mmol range, ideal for early to mid-clinical trial production. It supports production of hundreds of grams of therapeutic oligonucleotide active pharmaceutical ingredients (APIs) per lot, enabling a daily manufacturing throughput.

Key technical features include:

Widely adopted in pharmaceutical oligonucleotide manufacturing and molecular diagnostics, this system is critical for applications in gene editing research, synthetic biology, and bioprocessing pipelines requiring scalable and compliant oligonucleotide production. Its compatibility with shift operations allows capacity expansion exceeding 50 kg/year, supporting biopharmaceutical production and molecular cloning workflows.

This equipment provides researchers and process engineers with a robust, scalable solution for therapeutic oligonucleotide synthesis, emphasizing safety, operational efficiency, and regulatory compliance vital for biotechnology and clinical research applications.