Agilent 400-DS Automated Dissolution Tester

The Agilent 400-DS Apparatus 7 Dissolution Tester is operated by software designed to comply with 21 CFR Part 11 guidelines, offering significant convenience, increased throughput, and efficiency for your Quality Control (QC) and Research & Development (R&D) operations. It supports a variety of standard and custom holders, including those for drug-eluting stents, pacemaker leads, medicated contact lenses, and catheters.

This advanced lab equipment performs automated small-volume dissolution testing using as little as 3 mL media volume in either 5 or 10 mL sample cells. It saves precious time by allowing simultaneous testing of up to 13 samples, or 12 samples along with a control or standard, providing users direct visibility of each dissolution cell.

Temperature control is maintained via internal probes and external heating jackets, eliminating the necessity for a water bath. The system minimizes evaporation with a fully closed design and features an integrated syringe pump and autosampler to conserve bench space. It supports the automated addition and removal of up to five different media types through a port at the cell's bottom.

Sample holder reciprocation is facilitated through an externally controlled magnetic plate, accommodating between 1 and 35 dips per minute (DPM) to match your testing requirements. The device accommodates 12 individual sample rows with either 2 or 4 mL HPLC vials for unattended sample collection.

Users can program up to 36 timepoints and five media types into a method, with software prompts for rack removal and replacement during the run. The built-in fluidics module automates full or partial media replacement at each timepoint for each sample cell. A single PC can independently control up to four 400-DS systems, all managed by 21 CFR Part 11 compliant software.