Waters Acquity UPLC Sample Manager Model 186015006 for Liquid Chromatography Systems

The Waters Acquity UPLC Sample Manager 186015006 is a precision autosampler designed for ultra-performance liquid chromatography (UPLC) systems, widely adopted in molecular diagnostics and biopharmaceutical research workflows. Key features include an advanced XYZZ needle-in-needle design, which enhances sample injection accuracy and reduces carryover, critical for sensitive analyses in biotechnology and synthetic biology applications. It supports loop off-line mode and can utilize two degassed wash solvents to maintain sample purity and system stability during extensive runs.

Constructed with durable wetted materials such as titanium alloy and 316 stainless steel, it accommodates diverse solvents and complex biological samples typical in bioprocessing and environmental analysis. The unit operates at 120V, with compatibility for both 50Hz and 60Hz frequencies, ensuring global laboratory integration. Although currently sold AS-IS for parts and repair due to powering and connector issues, this sample manager holds valuable components essential for restoring high-throughput liquid chromatography sample handling used in gene editing, molecular cloning, and clinical diagnostics.

Its compact design supports minimum sample volumes of 5 µL using 2-mL vials, making it suitable for precise, low-volume injections in biotechnology workflows. This autosampler is integral in UPLC systems for high-sensitivity chemical mixture analysis, widely used across biomanufacturing and biomedical engineering sectors. Expert repair is required to restore full functionality, but salvaged parts remain critical for maintaining existing Waters UPLC liquid chromatography platforms.