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Beckman Coulter PA 800 plus Capillary Electrophoresis System with PDA Detector for Pharmaceutical Analysis
Product Description
The Beckman Coulter PA 800 plus Pharmaceutical Analysis System is a specialized capillary electrophoresis (CE) platform engineered for regulated pharmaceutical and biotechnology laboratories. It integrates high-voltage CE separations, an advanced 256-element diode array PDA detector, and temperature-controlled capillary and sample handling to ensure precise, reproducible biomolecular separations critical for biopharmaceutical purity profiling and molecular diagnostics.
Key features include:
- PDA Detector with 256 photodiode elements and a 30W deuterium UV source, offering a 190–600 nm wavelength range with ±2 nm accuracy for sensitive absorbance and fluorescence detection.
- 8-position filter wheel preloaded with filters at 200, 214, 254, and 280 nm enhancing detection specificity.
- Temperature control system spanning from 20°C below ambient to 60°C for sample and capillary, maintaining run-to-run stability and vital for charge variant and molecular weight assays.
- Precise pressure and vacuum control (injection: 0.1–25 psi pressure/0.1–5 psi vacuum; rinse: 0.1–100 psi pressure/0.1–5 psi vacuum) enabling controlled sample introduction and system rinsing.
- Automated fluidics and sample handling accommodating standard 32-vial buffer racks and microplate adapters for high-throughput bioprocessing workflows.
- Robust safety interlocks and monitoring for compliant operation in pharmaceutical quality control labs.
- Compact bench footprint (approx. 73.7 × 63.5 × 72.4 cm) and 85.3 kg weight designed for regulated lab environments requiring long-term reliability and ease of maintenance.
The PA 800 plus system is widely adopted in synthetic biology research, molecular diagnostics, and biopharmaceutical manufacturing pipelines for critical assays including:
- Charge variant analysis of therapeutic proteins and monoclonal antibodies (IgG purity/heterogeneity).
- SDS molecular weight and size-based biomolecule separations.
- Capillary isoelectric focusing (cIEF) for charge-based biomolecule profiling.
- Carbohydrate and impurity analysis.
- Identity testing and quality control assays aligned with regulatory requirements.
This CE system supports laboratory domains such as biotechnology, analytic biochemistry, clinical diagnostics, and pharmaceutical bioprocessing, providing reliable, high-resolution electrophoretic separations essential for molecular cloning workflows and biomanufacturing quality assurance. The PA 800 plus includes the PA 800 Plus control software (32 Karat Version 10) to facilitate seamless instrument operation and data acquisition.
With its combination of sensitive UV/PDA detection, temperature-controlled capillary environment, and precision fluidics, the Beckman Coulter PA 800 plus is a critical instrument for laboratories engaged in biopharmaceutical purity and impurity profiling, fluorescence analysis, and pharmaceutical QC applications. It ensures reproducibility, robustness, and compliance essential for regulated environments and advanced biotechnology research.
Item Stats
Product details
| Stock | In Stock |
| Brand | Beckman Coulter |
| Product Code | 64395 |
| Condition | Pre-Owned |
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