Advion Interchim PuriFlash 5.250 Preparative Flash Chromatography System with Integrated UV Detection and Automated Fraction Collection

The Advion Interchim PuriFlash 5.250 is a preparative flash chromatography system designed for high-throughput and scalable purification workflows in synthetic organic chemistry and biotechnological applications. This system supports flow rates from 1 to 250 mL/min with precise flow rate repeatability (<0.25%) and high linearity (0.98–1.0), capable of operating at pressures up to 250 bar (3625 psi). The platform features a quaternary gradient valve enabling complex solvent gradients with a gradient tolerance of less than 3.5%, essential for optimizing compound separation in pilot-scale and process chemistry settings.

Key components include:

This system’s design caters to advanced purification workflows required in medicinal chemistry, synthetic biology, and biopharmaceutical production pipelines. It is widely adopted in gene editing, molecular cloning workflows, and bioprocessing research due to its scalability, precision gradient control, and automated fraction collection. The system is lightweight (total weight 54 kg distributed across control, pump, and fraction collector units) and powered by 110-240 VAC for versatile laboratory integration.

Additional options include varied collection rack sizes and complementary C18 preparative columns for method customization. The PuriFlash 5.250 system is fully inspected, tested, and supported by warranty and after-sales technical consultation, ensuring reliability for research professionals requiring high-throughput purification with biotechnological and pharmaceutical applications.

Primary keywords: preparative flash chromatography system, UV detector, fraction collector, gradient valve, high-capacity chromatography, bioprocessing purification
Long-tail keyword phrases: scalable preparative flash chromatography for medicinal and process chemistry, automated fraction collection for biopharmaceutical production pipelines, high-pressure flash chromatography system with diode array detection, essential for molecular cloning workflows and synthetic biology research

This system’s robust industrial-grade construction and integrated components make it an essential instrument for laboratories focused on clinical diagnostics, biomanufacturing, and fluorescence analysis workflows requiring precise, reproducible compound isolation at preparative scale.