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Unchained Labs Uncle Protein Stability Analyzer Unit 1 for Biophysical Protein Stability Profiling
Product Description
The Unchained Labs Uncle Protein Stability Analyzer Unit 1 is an advanced biophysical characterization instrument widely used in biotechnology and molecular diagnostics for protein stability analysis and aggregation studies. Integrating full-spectrum fluorescence, static light scattering (SLS), and dynamic light scattering (DLS), it requires minimal sample volumes (~9 µL sealed capillaries) and supports high-throughput screening of up to 48 simultaneous samples per run.
Key technical features include:
- Protein Stability Metrics: Accurate measurement of thermal melting temperature (Tm) and aggregation onset temperature (Tagg) with <2% CV for Tm.
- Sample Concentration Range: 0.05–300 mg/mL for IgG; capable of analyzing biologics and protein therapeutics across broad concentration ranges critical in bioprocessing and synthetic biology workflows.
- Temperature Control: Precise thermal ramping from 15 to 95 °C with ±0.1 °C accuracy and heating rates from 0.1 to 10 °C/min enables isothermal and thermal ramp stability studies.
- Fluorescence and SLS Detection: Dual excitation lasers at 266 nm and 473 nm with CCD spectrometer covering a 250–720 nm spectral detection range enhance sensitivity for molecular diagnostics applications. SLS can resolve ~15 kDa molecular mass changes.
- Dynamic Light Scattering: Hydrodynamic diameter sizing from 0.3 to 1000 nm with ±2% accuracy, detecting polydispersity and particle sizing essential for biomanufacturing and gene editing research.
- Sample Integrity: Supports viral genome concentration detection ≥5 x 10^11 viral genomes/mL, enabling applications in AAV vector characterization and viral particle stability analysis.
This compact, fully serviced analyzer offers robust calibration, software integration, and intuitive operation. It is a critical tool for protein aggregation analysis, thermal stability profiling, and viscosity assessment in biotechnology, biopharmaceutical development, and biomedical engineering. The instrument’s combined fluorescence, SLS, and DLS modalities facilitate comprehensive molecular stability studies with minimal sample consumption, making it essential for workflows involving molecular cloning, synthetic biology, and bioprocess optimization.
Applications and Features:
- Thermal melting (Tm), thermal aggregation (Tagg)
- Isothermal stability studies and thermal recovery
- Sizing, polydispersity, and viscosity (kD, B22, G22, ΔG) measurements
- High-throughput screening with simultaneous analysis of 48 samples
- Compatible with biologics, proteins, and viral particles
- Remote installation, training, and US/International warranty support
This instrument supports critical research in molecular diagnostics, bioprocessing pipelines, and biopharmaceutical production by enabling precise biophysical profiling of therapeutic proteins and viral vectors with fast, reproducible results.
Item Stats
Product details
| Stock | In Stock |
| Brand | Unchained Labs |
| Product Code | SM101017-U1 |
| Condition | Pre-Owned |
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