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Agilent 6545A Q-TOF Mass Spectrometer with 1260 Infinity II LC System
Product Description
The Agilent 6545A Q-TOF Mass Spectrometer paired with the 1260 Infinity II LC System provides advanced mid-range quadrupole time-of-flight mass spectrometry with enhanced resolving power and sensitivity.
- Mass Range: m/z 100 to 10,000
- Mass Accuracy: <0.8 ppm RMS
- Spectral Acquisition Rate: 50 spectra/second (MS mode), 30 spectra/second (MS/MS mode)
- Sensitivity: Up to 5× improvement over previous models, optimized for small molecule analysis
- Ion Optics: Robust ion optics and beam shaping technology extend maintenance intervals and improve consistency
- Electronics: New high voltage pulsers and power supplies enhance mass resolution and accuracy
- Dynamic Range: Up to five decades allowing a broad range of sample concentrations
- Ion Modes: Fast switching between positive and negative ion modes in 1.5 seconds
- Detector: New-generation detector with improved longevity, high sensitivity, and wide dynamic range
- Software: Includes MassHunter suite with advanced data-mining and rapid analysis tools
- Applications: Pharmaceutical research, food safety, environmental testing, metabolomics, lipidomics, small molecule analysis
The 1260 Infinity II LC System components include:
- G7115A Diode Array Detector (tests: filter, dark current, holmium oxide spectrum, lamp intensity, wavelength accuracy, baseline noise)
- G7112B Binary Pump (pressure test up to 400 bar, leak test)
- G7116A Multicolumn Thermostat (Peltier cooling/heating performance)
- G7167A Multisampler (injector sequencing validation)
- System Test: 4 Peak Test to confirm overall LC functionality
The system is factory calibrated and certified, delivered with all necessary accessories for installation, and fully tested to meet original specifications.
Product details
| Sensitivity, MS Mode, Electrospray On-Column, 400 uL/min Flow Rate | 500:1 RMS (1 pg LC/MS injection of reserpine. Signal-to-noise for the reserpine (M+H)+ at m/z 609.2807 while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode) |
| Sensitivity, MS/MS Mode, Electrospray On-Column, 400 uL/min Flow Rate | 1,500:1 RMS (1 pg LC/MS injection of reserpine. Signal-to-noise for most intense product ions (174, 195, 397, and 448 m/z) while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode) |
| Mass Resolving Power | 45,000 FWHM at m/z 2,722 (measured after automatic tuning procedure) |
| Mass Accuracy - MS Mode, Electrospray On-Column, 400 uL/min | Less than 0.8 ppm RMS as measured from 10 repeat injections (measured at the (M+H)+ ion of reserpine (m/z 609.2807) using an internal mass reference) |
| Mass Accuracy - MS/MS Mode, Electrospray On-Column, 400 uL/min | Less than 2 ppm RMS on m/z 397 as measured from 10 repeat injections (product ion m/z 397 for reserpine) |
| Dynamic Range | Up to 5 decades (intrascan dynamic range on co-eluting components) |
| Mass Range | m/z 100 to 10,000 for extended mass range m/z 50 to 1,700 or 50 to 3,200 for both high resolution and extended dynamic range modes Quadrupole up to m/z 4,000 |
| Spectral Acquisition Rate, MS Mode | 50 spectra/second (m/z 50 to 1,700 in MS mode while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode) |
| Spectral Acquisition Rate, MS/MS Mode | 30 MS/MS spectra/second (m/z 50 to 1,700 in MS/MS mode while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode) |
| Positive to Negative Switching | 1.5 seconds (complete cycle switching from positive to negative and positive modes allow for stabilization time) |
| Dimensions (H x D x W) | 76 x 30 x 48 in. (193 x 76.2 x 121.9 cm) |
| Weight | 375 lb. (170 kg) |
| Electrical Requirements | 200-240VAC, 50/60Hz |
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