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Beckman Coulter Multisizer 4e Electrical Sensing Zone Particle Size Analyzer
Product Description
The Beckman Coulter Multisizer 4e is a high-precision electrical sensing zone particle size analyzer designed for real-time, multichannel particle counting and sizing. It operates over a broad particle diameter range from 0.2 µm to 1600 µm using apertures between 10 µm and 2000 µm, offering extended measurement range options of 2–80% of aperture size.
Key technical features include:
- Digital pulse processing providing dynamic size measurement and up to 525,000 pulses per analysis for high-resolution data.
- Measurement linearity with diameter accuracy of ±1% and volume accuracy of ±3%, critical for precise bioprocessing monitoring.
- User-configurable resolution and up to 400 size classes for customized particle size distribution analysis.
- Advanced software for calculating statistical parameters, enabling detailed evaluation of particle dynamics such as aggregation and cell-mediated responses—essential for molecular diagnostics and bioprocessing workflows.
- Integrated Ez access system to monitor fluid levels and electrolyte status, assuring consistent operation during long biomanufacturing runs.
- Support for both aqueous and non-aqueous electrolytes compatible with laboratory-grade materials such as glass and fluoropolymers.
- Dosing system designed for even suspension flow with a measurement error below 0.5%, ensuring reproducible sample handling.
Dimensions are 24 x 44 x 19 inches, and the unit weighs 100 lbs, powered by 100–240 VAC, 50/60 Hz supply with 210 W consumption.
This instrument is widely used in biotechnology research, synthetic biology, cell imaging, and clinical diagnostics, particularly for applications requiring reliable, high-throughput particle size distribution data. It is critical in biopharmaceutical production pipelines and molecular cloning workflows to monitor and control particulate characteristics.
The Beckman Multisizer 4e complies with 21 CFR part 11, making it suitable for regulated environments in pharmaceutical and biotechnology industries. Its real-time data reporting and flexible data export options support comprehensive analysis for research professionals seeking advanced particle characterization solutions.
Item Stats
Product details
| Particle Size Analysis Range: | Diameter: 0.2 — 1,600 µm Volume: 0.004 — 2.145 x 109 µm3 (fl) |
| Aperture Size | 10 — 2,000 µm (nominal diameter) |
| Measurement range | Extended: 2 — 80% of aperture size Standard: 2 — 60% of aperture sizeessary. |
| Measurement linearity: | Diameter: ± 1% Volume: ± 3% |
| Dynamic range (accuracy) | Diameter: 1 : 40 (extended), 1 : 30 (standard) Volume: 1 : 64,000 (extended), 1 : 27,000 (standard) |
| Processor type | High speed signal digitalization processor |
| Number of pulses measured | Up to 525,000 per analysis |
| Resolution | User defined |
| Number of size classes | Up to 400 for display of any selected measurement range The number of classes and their width can be changed as needed |
| Pulse distribution data | X axis: time, registration sequence, pulse width Y axis: diameter, volume or voltage corresponding to pulse amplitude, pulse width, mean diameter, volume, or voltage corresponding to pules amplitude, average pulse width, pulse distribution by width |
| Particle size distribution data | X axis: diameter, volume, surface area Y axis: absolute number, percent content (%), number per ml, absolute volume, volume percentage (%), volume per ml, absolute surface area, surface area (%), surface area per ml |
| Sample registration mode: total number of particles | 50 — 500,000 counts |
| Sample registration mode: number of particles and measurement of parameters | 10 — 100,000 counts |
| Sample registration mode: time | 0.1 — 999 seconds with at 10 ms increments Standard registration time is 10 — 90 seconds |
| Dosage system | The dosing pump with even suspension flow across the aperture and volume measurement, error – less than 0.5% |
| Electrolyte type: | Aqueous and non-aqueous electrolyte solutions compatible with glass, fluoropolymers, fluoroelastomers and stainless steel. |
| Aperture Current Range: | 30 — 6,000 µA with 0.2 µA increments |
| Aperture current stability: | ± 0.4% of set value |
| Polarity error | Less than 0.5% |
| Weight | 100 lbs |
| Dimensions | 24x44x19 |
| Power | 100 – 240 VAC; 50/60Hz, 210W |
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