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Teledyne ISCO CombiFlash EZ Prep UV/ELSD Preparative Flash Chromatograph System with Dual UV and ELSD Detection
Product Description
The Teledyne ISCO CombiFlash EZ Prep UV/ELSD Preparative Flash Chromatograph System integrates flash purification and preparative-scale HPLC to deliver versatile compound separation and purification for biotechnology, pharmaceutical, and chemical research applications. This benchtop preparative chromatography system offers a dual-mode design enabling seamless switching between high-pressure prep HPLC and lower pressure flash chromatography, critical in bioprocessing and synthetic biology workflows.
Key Technical Features:
- Flow rate range: 5–200 mL/min with ±5% accuracy, supporting efficient preparative workflows from milligram to tens of grams scale.
- Pressure capability: Up to 3500 psi (240 bar) for high-pressure mode and 200 psi (13.8 bar) for flash operation, enabling purification of complex synthetic organic compounds and biochemical extracts.
- Detection: Dual detectors include variable wavelength UV detector (200–400 nm in 5 nm increments) and built-in ELSD (Evaporative Light Scattering Detector), allowing monitoring of analytes with and without UV chromophores—essential for molecular diagnostics and natural product isolation.
- Gradient capabilities: Binary gradient mixing using any two of four solvents with programmable linear, step, and isocratic gradients, ±3% gradient accuracy for precise separations.
- Sample handling: Automated self-cleaning Flash injection valve and Prep HPLC loop injection, enhancing reproducibility in purification processes for gene editing and biopharmaceutical production pipelines.
- Temperature control range: Ambient operation between 20°C and 40°C with ELSD drift tube at 30–90°C and spray chamber at 10–60°C, suitable for sensitive biomolecule purification.
- System dimensions: Compact footprint at 43 x 43 x 67 cm (17 x 17 x 26.5 in), weighing 43.6 kg (96.1 lbs), ideal for space-constrained laboratories.
- Power requirements: 100–240 VAC, 50/60 Hz for global compatibility.
This system is widely adopted in biotechnology research for applications including preparative-scale purification of synthetic compounds, isolation of reaction products in medicinal chemistry, and preparatory clean-up of biologically derived intermediates. Its combination of high-pressure preparative HPLC and flash chromatography modes makes it critical in biopharmaceutical production pipelines and molecular cloning workflows.
Included accessories: Intake hoses with weighted solvent filters, waste hoses, column bypass tube, power cable. Columns and glassware are sold separately, allowing customization of purification setups.
Operational Verification: The instrument undergoes rigorous testing including power/initiation checks, touchscreen calibration, RFID-based column/rack verification, pump priming, gradient and flow rate accuracy validation, and UV/ELSD detector functionality confirmed by caffeine test injections. This ensures reliable performance for complex purification tasks required in synthetic biology and molecular diagnostics.
Applications:
- Purification of synthetic organic molecules in pharmaceutical R&D
- Isolation and purification of biologically active natural products
- Preparative separation in molecular biology and gene editing workflows
- Clean-up of intermediates in chemical synthesis for biomanufacturing
- Preparative compound purification in clinical diagnostics and bioengineering
This Teledyne ISCO CombiFlash EZ Prep UV/ELSD System provides a robust, versatile platform optimized for preparative flash chromatography and high-pressure liquid chromatography, delivering precision and efficiency essential for advanced biotech and chemical research laboratories worldwide.
Item Stats
Product details
| Stock | In Stock |
| Brand | Teledyne Isco |
| Product Code | 65101 |
| Condition | Pre-Owned |
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