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Wyatt DynaPro PlateReader III Dynamic & Static Light Scattering Instrument WPR3-01
Product Description
The Wyatt DynaPro PlateReader III WPR3-01 is a high-throughput, automated dynamic and static light scattering (DLS/SLS) system optimized for nanoparticle sizing and protein aggregation analysis directly in industry-standard microwell plates (96-, 384-, or 1536-well). Ideal for biotherapeutic formulation, molecular diagnostics, and nanoparticle characterization workflows, it enables in situ measurements with minimal sample volume (down to 4 µL), eliminating fluid transfer and sample carryover.
Key technical features include:
- Nanoparticle size range (hydrodynamic radius by DLS): 0.5 to 1000 nm
- Molar mass range (by static light scattering): 1,000 Da to 1 MDa (dependent on conformation)
- Sensitivity: 0.125 mg/mL using lysozyme (14.4 kDa)
- Laser wavelength: 830 nm with programmable laser power (10% to 100%)
- Temperature control: Integrated 4°C to 85°C for thermal stability and denaturation studies
- Sample compatibility: Supports disposable microwell plates ideal for high-throughput bioprocessing and protein crystallization screening
This instrument is widely adopted in biotechnology and biopharmaceutical research, providing critical support for synthetic biology, gene editing vector analysis, and biomanufacturing process development. Its robust software suite (Dynamics v7.8.1.3) facilitates efficient data acquisition and analysis, although it does not include 21 CFR Part 11 compliance security options.
Applications encompass:
- Protein aggregation and oligomerization studies
- Viral and non-viral gene vector characterization, including AAV titer analysis
- Formulation screening and stability testing for biotherapeutics
- Optimization of protein crystallization
- Screening for reversible self-association and viscosity behavior in high-concentration proteins
The DynaPro PlateReader III is essential for molecular diagnostics laboratories and research groups focusing on nanoparticle-based drug delivery, live-cell assay development, and fluorescence-free analytical methods. Designed to improve throughput and reproducibility, it is an indispensable tool for bioprocessing workflows, providing precise and reproducible nanoparticle and macromolecular characterization critical to modern biotechnology and clinical diagnostics.
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